Project Overview: Development of Chemical Probes Against USP5 Zf-UBD
Ubiquitination can mark proteins for degradation, alter their cellular location, affect their activity, and promote or prevent protein interactions. Ubiquitin specific proteases (USPs) are the largest family of deubiquitinase enzymes. USP5 disassembles unanchored ubiquitin chains. This prevents the accumulation of ubiquitin chains which would otherwise compete against ubiquitinated proteins for degradation as well as replenishes the Read More …