A growing team of groundbreaking scientists around the world are now sharing their lab notebooks online
Written in collaboration with Tigran M. Abramyan (Alexander Tropha’s lab at UNC Chapel Hill) In my previous open lab notebook entry I described the in silico approach using the program SparkTM to grow fragments found to co-crystallize within binding site A of the transcription factor brachyury to compounds with hopefully higher binding potency. The overall aim Read More …
The protein kinase N3 (PKN3) represents one of the understudied kinases in the human kinome and therefore one of the kinases SGC-UNC wants to target. As part of the UNC-SOLAR program, a summer program for students, Guillermo Correa Otero was working with me in the lab for 9 weeks. Under the supervision of David Drewry, Read More …
In order to develop ligands addressing different possible binding sites of the transcription factor brachyury, fragments co-crystallized with this protein should be developed into ligands by using the program SparkTM (Cresset®). Brachyury (T, TBXT) is an essential regulator of the notochord development. Brachyury is primarily expressed in the embryo but not in the majority of normal Read More …
At SGC we are interested in developing protein kinase inhibitors with a high selectivity towards other protein kinases. Based on lead compounds from the literature and our group new and selective CDKL2 inhibitors should be designed, synthesized and tested. Carla Alamillo, a former member of our group, worked on this topic and mentioned in her Read More …
