A growing team of groundbreaking scientists around the world are now sharing their lab notebooks online
I have been busy in the lab working at the bench and training our new recruits to the Huntington’s disease research team! Welcome Jacob and Claudia! Using a technique called BioID, we have identified proteins which are proximal or nearby to the HTT protein in cells. To date, no published literature details the use of Read More …
It has now been almost 2 years since I set out to try and make fragments of the huntingtin protein which might be amenable to structural analysis with X-ray crystallography. X-ray crystallography is a fantastic method and allows us to see the molecules in very fine atomic detail which is important if we are to Read More …
Update on meetings, manuscripts and mighty cool experiments…
Optimisation of HTT-HAP40 purification using heparin affinity chromatography
Manuscript finished! Design and characterisation of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems
Huntington Society of Canada 2018 Conference in Kelowna
Biophysical investigation of HTT and HTT-HAP40 using DSLS and SAXS
Searching far and wide for proteins that bind huntingtin
Expression and purification of the HTT-HAP40 complex with expanded polyQ (Q54)
The ongoing quest for huntingtin interaction partners
