A systematic review of drug-like ligands bound to helicases in the PDB
Introduction A current focus in the field of antiviral drug discovery are helicases, which are motor enzymes responsible for ATP-dependent nucleic acid duplex unwinding. Helicases of all superfamilies (SF) have stretches of amino acids called motifs, that are conserved within an SF and similar across SFs. For this reason, established helicase inhibitors interacting with these Read More …