A growing team of groundbreaking scientists around the world are now sharing their lab notebooks online
Hello again, Three weeks have now passed since my first blog, and the response has been overwhelming, who knew this kid with a love of dinosaurs could become an internet blogger. Your encouragement to make my t-Rex has motivated me to do just that, so let’s see how it all goes. Also fun fact, the Read More …
Update on meetings, manuscripts and mighty cool experiments…
In a collaboration between SGC-University of North Carolina-Chapel Hill and M4K Pharma, we plan to synthesize 3 different imidazopyridin pyrazines as promiscuous kinase ALK2 inhibitors, compounds 1-3, Scheme 1. The first step will be the synthesis of key intermediate 10, Scheme 2. The proposed synthesis begins with a nucleophilic aromatic substitution on compound 4 to Read More …
In this post I’d like to return to looking at my work on phosphorylation. Phosphorylation is a key signalling method for activating the BMP pathway and inducing activity. Specifically activation of ALK2 by phosphorylation leads to phosphorylation of SMAD1 which leads to gene transcription that ultimately is responsible for bone formation. In this post I’m Read More …
In a previous post, I tested hit analogues against USP5 Zf-UBD using a SPR assay. Compound AE-641/11456811, now aptly re-named XSR00035795a (an SGC global ID- since our database infrastructure is finally re-vamped), had a binding affinity of approximately 60 µM. The addition of a methyl group on the carboxylic chain of the compound increased potency Read More …
