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Background WDR5 belongs to the WD-repeat protein family and is an important component of various complexes, including SET1/MLL, NuRD, and NSL complex. It interacts with several binding partners via the “WDR5-interacting” (Win) site (e.g. symmetrically dimethylated histone H3R2, MLL1-4, SET1-2) or “WDR5-binding motif” (WBM) site (e.g. c,l,n-MYC, RBBP5). WDR5 emerged as a prime target Read More …
Background Transcriptional coactivators p300 and CBP catalyze the acetylation of lysine residues of a large variety of histone and non-histone proteins (PMID:28426192). p300 and CBP are considered functional homologous proteins that share around 86% amino acid sequence identity in the HAT domain (PIMID:7870179). The upregulation of p300/CBP has been associated with various cancers, indicating an important role in Read More …
