Taking Aim and Firing at TBXT to Combat Chordoma

Hello! My name is Nergis Imprachim and I am just another soldier in the army of science, serving Opher Gileadi’s team under the command of Sergeant Joseph Newman at CMD, University of Oxford. My enemy is disease, chordoma in particular. Chordoma is a bone cancer affecting the skull base and spinal cord. It is a Read More …

TBXT ligands for Chordoma: lactams for pocket F

Our initial fragment screen identified four different fragments that bound to what we call site F (Figure 1) These can be found in the Protein Data Base (pdb) with these codes: 5QSA, 5QSC, 5QSI, and 5QSK. In this blog I will talk about some observations from these structures that suggest promise for this pocket, show Read More …