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Amy Ramsey

Development of mouse line with Grin1 variant Y647S

Posted on27th August 2019AuthorAmy Ramsey1 Comment

This is a test to figure out how we add links to zenodo lab notebooks, which are time stamped and have a DOI. I uploaded an image of our Sanger sequence that shows the introduction of base pair changes to cause an amino acid substitution Y647S. https://zenodo.org/record/3379009#.XWVmfpNKhp8

CategoriesAmy Ramsey, Amy Ramsey (Univ. of Toronto), GRIN disorder, NMDA, Rare disease

Open Science for GRIN

Posted on23rd August 2019AuthorAmy RamseyLeave a comment

For the Ramsey Lab, this project began in 2018, when we were invited to a parent-organized meeting for caregivers of GRIN1 patients. Our group uses mice to study the NMDA receptor (which is encoded by the GRIN genes) in the context of schizophrenia and autism. It was only in 2018 that we learned of a Read More …

CategoriesAmy Ramsey, Amy Ramsey (Univ. of Toronto), GRIN disorder, NMDA, Rare disease

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      • Sean O’Byrne
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      • Batten disease
      • Chordoma
      • COVID-19
      • Diffuse intrinsic pontine glioma
      • Ependymoma
      • Fibrodysplasia ossificans progressiva
      • GRIN disorder
      • Huntington’s disease
      • Influenza
      • iPSC Disease modelling
      • Leukemia
      • Malaria
      • Parkinson’s disease and neurodevelopmental disorders
      • Primary Hyperoxaluria
      • Rare disease
    • Past
      • Dravet syndrome
  • Projects
    • Active
      • ACVR1/ALK2
      • ALS-Reproducible Antibody Platform (ALS-RAP)
      • Cell assay reports
      • Chromatin factors
      • E3 ligases
      • Epigenetic targets in Medulloblastoma
      • EZHIP
      • GTPase-GEF complex
      • HAO1
      • HDACs
      • HERO Glove
      • Huntingtin
      • Influenza computational genomics
      • Investigating Outdoor Mobility of Older Adults
      • iPSCs
      • Ligandable Genome
      • NMDA
      • NSD3
      • Open Secretion Rescue
      • PRC2
      • PRDM methyltransferases
      • PRMTs
      • Protein purification protocols
      • SARS-CoV-2 computational genomics
      • SARS-CoV-2 NSP14
      • SETDB1
      • Spike
      • TBXT (brachyury) inhibitors
      • Toronto Open Access SARS-CoV-2 Protein Manufacturing Center
      • TREAT-AD
      • Understudied Kinases
      • USP5
      • USPs
      • WDR proteins
      • WDR41
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    • Past
      • EGFR and GAK
      • Gene therapy for Dravet Syndrome
      • In silico PROTACs design
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    • Rachel Harding: 3D structure of Huntingtin
    • Setayesh Yazdani: the druggable human genome
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