A growing team of groundbreaking scientists around the world are now sharing their lab notebooks online
Our chordoma research focused on developing small reversible molecules targeting the transcription factor TBXT which codes for the brachyury protein. Brachyury contains several shallow pockets, and through an x-ray crystallography fragment based approach we previously identified several series of small fragments bound to it (TBXT Fragment Hits). Our medicinal chemistry project aimed to grow the Read More …
By Zachary Davis-Gilbert, Anwar Hossain, and David H. Drewry* In conjunction with our efforts to target TBXT via non-covalent small molecules, we have also been developing covalent compounds that bind to CYS122, which has previously been shown to be accessible by afatinib (pdb code 6ZU8). In this blog post, I will discuss the progress made Read More …
In vivo characterization of antibodies directed against TREAT-AD target proteins in mouse model of AD pathology Suzanne Doolen, Riham Ayoubi, Carl Laflamme, Ranjita Betarbet, Elizabeth Zoeller, Sean-Paul G. Williams and Stacey J. Sukoff Rizzo https://doi.org/10.5281/zenodo.6612215 Our goal in support of the Emory-Sage-Structural Genomics Consortium (SGC) TREAT-AD Center is to develop and identify high-quality tools to Read More …
