Updates on the huntingtin PAR binding story can be found on the Truant lab website.
Hypothesis: Poly ADP ribose signaling is dysregulated in Huntington’s disease
Is huntingtin a PAR-binding protein?
A closer look at the hits generates 2 new hypotheses
Next steps in the identification of ROS-related huntingtin protein-protein interactions
ROS-dependent huntingtin interactions in mouse striatal cells
Update: Measuring DNA repair capacity and visualizing huntingtin in HD patient cells
Visualizing real huntingtin protein in cells from an HD patient
Measuring the rate of DNA repair in HD cells
Pulling huntingtin-associated DNA repair proteins out of HD patient cells