March 2022 – openlabnotebooks.org

Release of brachyury (TBXT) SPR Raw Data

Posted on31st March 2022AuthorAnwar Hossain2 Comments

This week we released our Surface Plasmon Resonance (SPR) data for the binding of small molecules to brachyury (gene name TBXT) on Zenodo (https://doi.org/10.5281/zenodo.6394811). The raw data was collected by HD Biosciences as part of an ongoing campaign to identify potent ligands of this transcription factor that is critically important to chordoma cells. This upload Read More …

TBXT ligands for Chordoma: Thiazoles for pocket A’

Posted on29th March 20227th January 2023AuthorAnwar HossainLeave a comment

During our initial fragment screen for brachyury, we identified two fragments that bound to pocket A’. These two structures can be found in the Protein Data Base (pdb) with codes: 5QS9 and 5QSD. To date, this site and the derivatives of these two fragments represent some of our most promising targets for targeting brachyury. In Read More …