Analysis of fragments that bind to HAO1

In my previous post, I introduced our fragment screening results on HAO1. Specifically, I told you that we identified five promising fragment hits, from a little over 400 collected structures, clustering to three biologically relevant sites: the active site (fragments 1 and 2), the gating loop (fragment 5) and the subunit interface (fragments 6 and Read More …

Speaking at the annual conference of the Society for the Study of Inborn Errors of Metabolism (SSIEM)

Hello again! This week I am in sunny, sunny Athens attending the SSIEM annual conference that brings together renowned experts in inborn errors of metabolism from around the world to present their latest pre-clinical and clinical research. I was fortunate enough to receive a generous travel grant from the SSIEM to give a talk this Read More …

Identifying fragments that bind to HAO1 by x-ray crystallography

In this post, I would like to share my recent work on HAO1 fragment screening by crystallography, as a means to identify inhibitor starting points. So why fragment screening by x-ray crystallography? Well there are two components to my method of choice: Fragments instead of complex compounds provide good starting chemistry Fragments are less than Read More …

Project overview: Inhibition of HAO1 to treat primary hyperoxaluria type 1

Hello everybody! I am Sabrina, a third year DPhil student in Wyatt Yue’s lab at the SGC University of Oxford, co-supervised by Paul Brennan. I am fascinated by how a single base change in an enzyme-coding gene can lead to a diverse group of symptoms and how the severity of such diseases can be reduced Read More …