CaMKK2 Inibitors: Quinoline Analogs

In my last post, I reported a new synthetic route to our quinoline series, Scheme 1. The goal was to overcome prior synthetic challenges and to allow for rapid synthesis of many different analogs over a short period of time.

Scheme 1: New synthetic route for generating quinoline analogs

I have as a result generated large numbers of quinoline analogs which have been sent for testing – CaMKK2 binding assay. Examples of some of the completed analogs are provided below, Figure 1.

Figure 1: Prepared quinoline analogs (CaMKK2 Inhibitors)

I am currently analyzing all of the biological data received so far and they will be reported in due course.

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