A growing team of groundbreaking scientists around the world are now sharing their lab notebooks online
In order to develop ligands addressing different possible binding sites of the transcription factor brachyury, fragments co-crystallized with this protein should be developed into ligands by using the program SparkTM (Cresset®). Brachyury (T, TBXT) is an essential regulator of the notochord development. Brachyury is primarily expressed in the embryo but not in the majority of normal Read More …
Hi! I’m Opher Gileadi, I head a group at the Structural Genomics Consortium (SGC) in Oxford. For many years, we’ve been looking at proteins involved in human. We’ve looked at a wide variety of proteins: from DNA repair enzymes and transcription factors to enzymes involved in signalling. In most cases, we focus on early work: Read More …
A major therapeutic avenue for chordoma is targeting the receptor tyrosine kinase, EGFR. Its ligand, EGF, is overexpressed as a transcriptional target of Brachyury and polysomy of EGFR’s region of chromosome 7 is frequent in chordoma. To this extent I, in collaboration with SGC-UNC’s post-doc Chris Asquith, am working on the profiling of a number Read More …
Greetings! My first post here will be a brief introduction. More in-depth experiment and data posts are coming soon! I am a post-doctoral research associate in the UNC Catalyst for Rare Diseases1. Throughout my education and training, I have been interested in cancer – I worked on epigenetics of ovarian cancer as an undergraduate and Read More …
