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Background WDR5 belongs to the WD-repeat protein family and is an important component of various complexes, including SET1/MLL, NuRD, and NSL complex. It interacts with several binding partners via the “WDR5-interacting” (Win) site (e.g. symmetrically dimethylated histone H3R2, MLL1-4, SET1-2) or “WDR5-binding motif” (WBM) site (e.g. c,l,n-MYC, RBBP5). WDR5 emerged as a prime target Read More …
Background The mammalian MYST1 is a member of the MYST family of histone acetyltransferases and is the primary enzyme that catalyzes the acetylation of histone H4 on lysine 16 (H4K16). Acetylation of K16 is a prevalent mark associated with chromatin decondensation. MYST1 has been shown to play an essential role in embryonic formation and development, Read More …
Hi, Recently, I have started working on NanoBret PPI technology for chromatin factors and E3 ligases are here is one of the assays I developed. Background (source: PMID28179136). The repressive Nucleosome Remodeling and histone Deacetylation (NuRD) complex alters chromatin structure by coupling ATP-dependent remodeling activity with histone deacetylation function. It is composed of six different Read More …
