Screening EGFR and GAK Inhibitors in Chordoma
A major therapeutic avenue for chordoma is targeting the receptor tyrosine kinase, EGFR. Its ligand, EGF, is overexpressed as a transcriptional target of Brachyury and polysomy of EGFR’s region of chromosome 7 is frequent in chordoma. To this extent I, in collaboration with SGC-UNC’s post-doc Chris Asquith, am working on the profiling of a number Read More …