A growing team of groundbreaking scientists around the world are now sharing their lab notebooks online
There have been some exciting developments in the lab since my last post…I’ve got apo crystals of USP5 Zf-UBD! Experimental details can be found on Zenodo. The apo structure, which has no ligands bound in the receptor pocket has already been solved. The purified protein sample I have been working with for USP5 Zf-UBD is Read More …
At the SGC-UNC we are interested in building a set of inhibitors that “covers” the whole kinome. Here’s a reference that talks about our plans for the Kinase Chemogenomic Set (KCGS): http://journals.plos.org/plosone/article/related?id=10.1371/journal.pone.0181585. We are building the set with what we call “narrow spectrum” inhibitors – inhibitors that inhibit only a small set of kinases. To help Read More …
