A growing team of groundbreaking scientists around the world are now sharing their lab notebooks online
A Happy New Year to all! I am back from vacation and ready to jump back into my work with USP5. Great news- we solved the co-crystal structure of USP5 with a promising compound, UBTR012574a (Figure 1) (discussed in my last post), just before the Christmas holidays. You can check out details about co-crystal growth, Read More …
In my previous post, I shared the expression and purification results of several constructs based on bacterial expression systems. Such experiments often fail as there are inherent complications with protein expression associated with bacterial expression systems. This was likely the case for most of our last batch samples. To tackle this problem, we decided to Read More …
About one quarter of the Eukaryotic genome encodes glycoproteins that are made in the Endoplasmic Reticulum (ER), and travel to special destinations such as the extracellular environment, the cell membrane or other organelles like the lysosomes. We can think of the ER as a nursery where baby glycoproteins quickly grow to attain their adult Read More …
A happy new year all. Yes I know, it’s already mid-January and we are nearly all done with our resolutions. But what better way for me to start back to the open notebooking/blogging than to kick off with a top 10 list of my resolutions/hopes for 2020 (some science/some aspirational). Yes, I am back blogging Read More …
