A growing team of groundbreaking scientists around the world are now sharing their lab notebooks online
Characterization and Assessment of KCNU1/SLO3 as a Potential Non-hormonal Contraceptive Target Introduction Project Proposal The Structural Genomics Consortium (SGC) has recently embarked on its first research project in reproductive biology as a part of the SGC’s new open science Women’s and Children’s Health Program (WCHP). This program, which was generously funded by the Bill & Read More …
Background The Bill and Melinda Gates Foundation awarded the Structural Genomics Consortium with the SGC Women’s and Children’s Health Initiative in September 2021. The initiative targets a group of proteins for effective non-hormonal contraceptive agents. Each target protein will be purified and characterized to screen for possible chemical probes and drug candidates. SGC-UNC was assigned Read More …
For clearer figures, please see this post at: https://zenodo.org/record/6993848#.Yv6Kwj3MI2w Introduction Project Proposal The Structural Genomics Consortium (SGC) has recently embarked on its first research project in reproductive biology as a part of the SGC’s new open science Women’s and Children’s Health Program (WCHP). This program, which was generously funded by the Bill & Read More …
Chemical probes typically bind off targets in addition to their intended target protein. Since it is hard to determine whether the phenotype is due to inhibition of the target protein or off-targets, the use of negative controls, which are structurally close to the probe but are inactive against the intended target, is highly recommended. Loss Read More …
Some very interesting date on the binding of WDR41, over 20 K screened with 52 hits. See Zenodo link for all information https://zenodo.org/record/4776602#.YKac-6hJGUk
As describe in my previous post, my goal is to discover non-catalytic druggable pockets in human enzymes. These pockets could potentially be exploited for the design of ProxPharm compounds (chimeric compounds that bring two proteins in close proximity to elicit an effect of one protein on the other1). An essential aspect for the design of Read More …
Today’s post focuses on another protein encoded by many coronaviruses, the non-structural protein 15 (nsp15), an endoribonuclease. Nsp15 is a nidoviral RNA uridylate-specific endoribonuclease (NendoU) with C-terminal catalytic activity. This protein belongs to the EndoU family, and they all carry an RNA endonuclease activity to produce 2’-3’ cyclic phosphodiester and 5’-hydroxyl termini. (Kim et al. Read More …
Today’s post focuses on another protein encoded in open reading frame 1a (ORF1a) of many coronaviruses, the non-structural protein 9 (nsp9). Nsp9 is thought to mediate viral replication. In SARS-CoV-1, nsp9’s role has been highlighted as a single-stranded RNA-binding subunit. (Egloff et al., 2004) The structure of SARS-CoV-2 nsp9 was solved in both apo and Read More …
Hello and happy new year! I am back from my winter break and starting to get back to research. If you have followed my previous posts, you know that I have posted the druggability and genetic variability analysis of several protein targets of SARS-CoV-2. There are a few targets that I will be posting in Read More …
I am currently completing my fourth-year thesis in Dr. Dalia Barsyte-Lovejoy’s lab. I have a strong interest in both pharmacology and biochemistry. I am interested in learning about biochemical pathways in the body, with the goal of finding compounds that can target those pathways and for them to potentially develop into therapeutics. My project focuses Read More …
