Roslin Adamson

ACVR1A purification for co-crystallisation with LDN-193189 for fragment screening

Posted onAuthorRoslin AdamsonLeave a comment

I haven’t done that much lab work lately as I have been working on crystal data processing among other things. However, a couple of weeks ago I purified some ACVR1/ALK2 for crystallisation for fragment screening (which happened on Friday) and for co-crystallisation with some of our compounds. The experimental details are here, on Zenodo. As Read More …

ACVR1 – the link between FOP and DIPG

Posted onAuthorRoslin Adamson2 Comments

Background What is the link between a rare genetic disease that causes soft tissues to turn to bone, and a lethal childhood brain cancer? At first glance, with such different clinical phenotypes, it seems unlikely there could be any link, but it has been shown through whole genome sequencing of diffuse intrinsic pontine glioma (DIPG) Read More …