A growing team of groundbreaking scientists around the world are now sharing their lab notebooks online
To start off my project at the SGC, my supervisor, Dr. Rachel Harding, and I produced and purified three proteins. These proteins were RAB1A, RAB1B, and MECP2. Both RAB1A and RAB1B have functions in the initiation of autophagy, which is a cellular system that helps clean out old debris and malfunctioning parts. MECP2 is a Read More …
Huntington’s disease (HD) is a progressive neurological disorder caused by a mutation in the HTT gene which encodes for the huntingtin protein. The current understanding of the function of HTT is limited, and there are only a few sources that indicate that it likely plays a critical role in several intracellular processes such as Read More …
Updates on the huntingtin PAR binding story can be found on the Truant lab website.
Update on meetings, manuscripts and mighty cool experiments…
Optimisation of HTT-HAP40 purification using heparin affinity chromatography
The experimental set-up and results covered in this post can be found here: 10.5281/zenodo.2541053. A lot has happened in the past few months and it is with mixed feelings that I am finishing up my postdoc here at SGC! I feel very privileged to have been part of the great science going on at SGC Read More …
Manuscript finished! Design and characterisation of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems
The experimental set-up and results covered in this post can be found here: 10.5281/zenodo.1495129. Apologies for the long delay between this post and my last post, it really has been quite some time! As postdocs, we generally have several projects running simultaneously and we have to split our time between these projects. I am no Read More …
Huntington Society of Canada 2018 Conference in Kelowna
Hypothesis: Poly ADP ribose signaling is dysregulated in Huntington’s disease
