Another small set of compounds was recently synthesized, the major change in Set2 is the substitution of the sulfur atom by oxygen or nitrogen. The change was made in position 6 of the pyrimidine ring. These compounds along with others from Set1 are currently under screening in the NanoBRET cellular assay (performed by Carrow Wells).
![](https://openlabnotebooks.org/wp-content/uploads/2018/05/DRAK2-Set2.png)
DRAK2 inhibitors-Set2
Good stuff Alfredo!