A growing team of groundbreaking scientists around the world are now sharing their lab notebooks online
In my previous post https://openlabnotebooks.org/protein-protein-docking-for-protac-discovery/ I showed that HADDOCK was the best protein-protein docking tool among those I tested to predict how E3 ligases interact with their protein substrates. Here, I ask whether docking virtual libraries of PROTAC candidates to these E3 ligase – substrate protein interfaces can be used to predict which PROTACs are active. Read More …
Someone pointed out a funny quirk of mine the other day. I love things that come in threes. I never realized it before, but then I started thinking about it, and before you could say thirty-three, I was contemplating all the threes I like. Maybe its because the house I lived in growing up was Read More …
Purifications of HTT and HTT-HAP40 from insect (Sf9) and mammalian (EXPI293F) expression systems
Summer travels showcasing the huntingtin protein toolkit
