Epigenetic targets in Medulloblastoma

Update #03 – Performing Dose-response assays of BAY-299 on medulloblastoma   I have been screening multiple medulloblastoma cell lines including ONS-76, D425, D458, and Med8A with BAY-299 and its negative control probe.  So far, three out of four lines have demonstrated sensitivity to the BAY-299 probe consistent with the screening results (Defining Epigenetic Drivers of Read More …

Update #02 – Screening Established Medulloblastoma Cell Lines The first part of my project involves screening medulloblastoma cell lines that successfully proliferate in vitro with SGC’s epigenetic probe library.  The idea of this work is to identify common epigenetic targets that influence medulloblastoma proliferation and could potentially be used as prognostic or therapeutic targets.   I Read More …

Defining Epigenetic Drivers of Medulloblastoma – Introduction  Medulloblastoma is a cancer that arises from neural progenitor cells in the brain.  This cancer most commonly occurs in young children ages 1-4, and is the most common type of childhood brain cancer.  Although many cases of medulloblastoma show good prognosis, there are some sub-types of this cancer Read More …