Jacob McAuley

Five months ago, I made my first post outlining the goals of my project here at the SGC. I am writing again today to update you on the progress I have made toward those goals. As a brief overview, I was working on finding Huntingtin (HTT) interacting proteins, but why would this be important? If Read More …

Back again. Two posts in one month! I know its crazy, but I’m just excited to tell you about the progress that is being made on this project. First things first, purifications. This week I have four more to tell you about. The first is GFP, and unlike all of my other posts, this is Read More …

Hello again! It has been a while since my last post but that is not for lack of data. Over the past month I have been purifying like crazy, adding more proteins to out bank of possible interaction partners. As we are now in the final month of the project, I want to take this Read More …

We are getting close to the midpoint of the summer and my project is well underway. With another week passed, I have more purifications to share. Again, I was attempting to purify proteins we think might interact with the huntingtin protein in neuronal cells. This time around was a little less successful than previous posts, Read More …

As the summer continues to progress, so does my project. After the last round of purification, detailed in my previous blog post, I am ready for another round. During this purification, I will be working with SH3G3 and PACN1. PACN1 is responsible for cytoskeletal remodeling through regulation of several other proteins, as well as neuronal Read More …

To start off my project at the SGC, my supervisor, Dr. Rachel Harding, and I produced and purified three proteins. These proteins were RAB1A, RAB1B, and MECP2. Both RAB1A and RAB1B have functions in the initiation of autophagy, which is a cellular system that helps clean out old debris and malfunctioning parts. MECP2 is a Read More …

  Huntington’s disease (HD) is a progressive neurological disorder caused by a mutation in the HTT gene which encodes for the huntingtin protein. The current understanding of the function of HTT is limited, and there are only a few sources that indicate that it likely plays a critical role in several intracellular processes such as Read More …