A growing team of groundbreaking scientists around the world are now sharing their lab notebooks online
Background: I have been characterising the cellular potency of many M4K compounds against ALK2 and ALK5. Compounds that targets ALK2 and not ALK5 should be further evaluated for their ability to reduce the viability of cells derived from DIPG patients. Although these cultured cells might not reflect what actually happens in a DIPG patient’s brain, Read More …
Back again. Two posts in one month! I know its crazy, but I’m just excited to tell you about the progress that is being made on this project. First things first, purifications. This week I have four more to tell you about. The first is GFP, and unlike all of my other posts, this is Read More …
This is a test to figure out how we add links to zenodo lab notebooks, which are time stamped and have a DOI. I uploaded an image of our Sanger sequence that shows the introduction of base pair changes to cause an amino acid substitution Y647S. https://zenodo.org/record/3379009#.XWVmfpNKhp8
For the Ramsey Lab, this project began in 2018, when we were invited to a parent-organized meeting for caregivers of GRIN1 patients. Our group uses mice to study the NMDA receptor (which is encoded by the GRIN genes) in the context of schizophrenia and autism. It was only in 2018 that we learned of a Read More …
Dear colleagues, I want to share with you all the poster presented this past spring 2019 at The American Chemical Society (ACS) National Meeting in Orlando, FL. This summaries our work on the synthesis of DRAK2 inhibitors.
Growing up I have always loved movies, and in particular movie villains. From Darth Vader in “Star Wars”, to the T-Rex in “Jurassic Park”, to the great white shark in “Jaws” and the villainous roundabout in “National Lampoon’s European vacation”, I have always been fascinated by what makes villains do what they do, what is their Read More …
Hi, My name is Carmen, and I a postdoc at the SGC in Oxford. I work in multidisciplinary projects in Paul Brennan and Opher Gileadi groups. Today I am going to introduce one of the projects I have been working for the last year which is part of the group’s endeavour to target small GTPases Read More …
Update #02 – Screening Established Medulloblastoma Cell Lines The first part of my project involves screening medulloblastoma cell lines that successfully proliferate in vitro with SGC’s epigenetic probe library. The idea of this work is to identify common epigenetic targets that influence medulloblastoma proliferation and could potentially be used as prognostic or therapeutic targets. I Read More …
In 1998, I did my Leaving. For those not from Ireland, you think ah OK, he left home and went away. But if you are from Ireland, you know exactly what I mean. It doesn’t mean I left home, it means I sat my leaving certificate examinations, exams that mark the end of secondary school Read More …
Hello again! It has been a while since my last post but that is not for lack of data. Over the past month I have been purifying like crazy, adding more proteins to out bank of possible interaction partners. As we are now in the final month of the project, I want to take this Read More …
